Keyword Analysis & Research: chimeric antibody
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What are chimeric antibodies? - ProteoGenix
https://www.proteogenix.science/scientific-corner/antibody-production/what-are-chimeric-antibodies/
WebMay 11, 2020 · Chimeric antibodies, once created to minimize the HAMA response, are now only sparsely developed for clinical applications. Today, they represent about 10% of all antibodies ever granted approval for clinical applications and are mostly used as intermediate molecules in antibody humanization.
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Chimeric Antibody - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/chimeric-antibody
WebChimeric antibodies are molecules made up of domains from different species. For example, the Fc region or all the constant regions of a mouse mAb may be replaced with those of a human or (any other species) antibody.
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What are Chimeric Antibodies? - News-Medical.net
https://www.azolifesciences.com/article/What-are-Chimeric-Antibodies.aspx
WebApr 9, 2021 · Some of the most notable chimeric antibodies that are currently approved by the FDA include infliximab, abciximab, basiliximab, cetuximab, and rituximab. Infliximab, for example, is a chimeric antibody that specifically targets tumor necrosis factor-alpha (TNF) to reduce inflammation in rheumatoid arthritis (RA) patients.
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Chimeric Antibody - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/chimeric-antibody
WebIt is used to treat CD20+ non-Hodgkin lymphoma and chronic lymphocytic leukemia, but also has been used as therapy for a variety of autoimmune diseases, including systemic lupus, RA, and pemphigus.
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Antibodies 101: Chimeric Antibodies - Addgene
https://blog.addgene.org/antibodies-101-chimeric-antibodies
WebApr 25, 2023 · Chimeric antibodies can help. A chimeric antibody is made by changing an antibody’s natural isotype to that of a different group (Fig. 1). This process, called isotope conversion, gives users the flexibility needed for multiplexing.
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Antibody Structure and Function: The Basis for Engineering …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963682/
WebDec 3, 2019 · In many cases, chimeric antibodies demonstrated reduced immunogenicity but still elicited some human anti-therapeutic antibody response . To further minimize immunogenicity, a CDR-grafting approach was proposed by G. Winter and coauthors . The procedure involves the transfer of CDRs from a non-human (very often murine) “parental” …
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Chimeric Antibody - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/immunology-and-microbiology/chimeric-antibody
WebChimeric Antibody. The chimeric antibody hCAb may be a promising candidate in the treatment of human colorectal cancer. From: Recent Advances in Cancer Research and Therapy, 2012. Related terms: Infliximab; Humanized Antibody; Monoclonal Antibody; Immunogenicity; Monospecific Antibody; Rituximab; CD20; Heavy Chain; …
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The global landscape of approved antibody therapies - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9535261/
WebSep 6, 2022 · There are a total of 16 approved chimeric antibody therapies which are in multiple formats, including naked whole IgGs, fragments, and antibody drug conjugates (ADCs). The first murine antibody therapy, Abciximab [ 10 , 11 ], was first approved in Cuba.
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Therapeutic antibodies: their mechanisms of action and the …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588207/
WebJun 15, 2015 · Rituximab (Rituxan ®) is a chimeric murine/human monoclonal antibody targeted against the pan-B-cell marker CD20. Rituximab binds to B cells that express CD20 and induces cell death through CDC or ADCC 34. CD20 is expressed in non-neoplastic B cells (pre, immature, mature, and activated) and neoplastic cells derived from B cells.
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Chimeric Antibody | Sino Biological
https://www.sinobiological.com/resource/antibody-technical/chimeric-monoclonal-antibody
WebChimeric antibodies are structural chimeras made by fusing variable regions from one species like a mouse, with the constant regions from another species such as a human being. Chimerization of antibodies is a necessary process to reduce immunogenicity and increase serum half-life when preparing monoclonal antibodies (mAbs) for therapeutic ...
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