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Chimeric Antigen Receptor T-Cell Therapy - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK537294/
WEBOct 3, 2022 · Chimeric antigen receptors (CARs) are recombinant receptors for antigens which redirect the specificity and function of T lymphocytes and/or other immune cells in a single molecule. The concept of using CARs in cancer immunotherapy is that CARs, which are programmed targeting tumor-associated antigens, can be replicated rapidly and …
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Chimeric antigen receptor T-cell therapy - Nature
https://www.nature.com/articles/nrclinonc.2017.148
WEBSep 19, 2017 · Chimeric antigen receptor (CAR)-T-cell therapy is a promising approach for the treatment of refractory malignancies, but is associated with unique acute toxicities that need...
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An introduction to chimeric antigen receptor (CAR) T-cell ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/30680780/
WEBAbstract. Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen.
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Chimeric Antigen Receptor (CAR) T-Cell Therapy
https://www.lls.org/treatment/types-treatment/immunotherapy/chimeric-antigen-receptor-car-t-cell-therapy
WEBTocilizumab (Actemra®) is approved for the treatment of adults and pediatric patients 2 years of age and older with chimeric antigen receptor (CAR) T cell-induced severe or life-threatening cytokine release syndrome (CRS).
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CAR T cell - Wikipedia
https://en.wikipedia.org/wiki/CAR_T_cell
WEBThe receptors are chimeric in that they combine both antigen-binding and T cell activating functions into a single receptor. CAR T cell therapy uses T cells engineered with CARs to treat cancer. T cells are modified to recognize cancer cells and destroy them.
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CAR T Cells: Engineering Immune Cells to Treat Cancer - NCI
https://www.cancer.gov/about-cancer/treatment/research/car-t-cells
WEBThey are made by collecting T cells from the patient and re-engineering them in the laboratory to produce proteins on their surface called chimeric antigen receptors, or CARs. The CARs recognize and bind to specific proteins, or antigens, on the surface of cancer cells.
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Chimeric Antigen Receptor-T Cell Therapy - PMC - National …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745952/
WEBFeb 2, 2018 · Chimeric antigen receptor (CAR)-T cell therapy is a new class of cellular immunotherapies that involves ex vivo genetic modification of T cells to incorporate an engineered CAR. After infusion into the patient, the CAR-expressing T cells recognize specific tumor targets and induce an immune response against them.
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Chimeric antigen receptor T cell therapy comes to clinical practice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193999/
WEBApr 1, 2020 · Chimeric antigen receptor T cell ( car - t) therapy, first conceptualized at the end of the 1980s, predicted that the body’s own immune cells could be repurposed to target cancer cells—if the correct target could be identified, and if the T cells would be stimulated on contact to mobilize effector, expansion, and survival mechanisms.
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Chimeric Antigen Receptors for T cell Immunotherapy: Current
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697438/
WEBThe genetic engineering of T cells through the introduction of a chimeric antigen receptor (CAR) allows for generation of tumor targeted T cells. Once expressed by T cells, CARs combine antigen-specificity with T cell activation in a single fusion molecule.
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What is chimeric antigen receptor-T cell therapy?
https://cancerblog.mayoclinic.org/2022/04/21/what-is-chimeric-antigen-receptor-t-cell-therapy/
WEBApr 21, 2022 · Mayo Clinic Minute: What is chimeric antigen receptor-T cell therapy. From an accredited US hospital. CAR-T cell therapy is a personalized treatment giving hope to patients diagnosed with various lymphomas. "Lymphoma in plain terms is essentially a cancer of your immune system," says Dr. Madiha Iqbal, a Mayo Clinic hematologist and oncologist.
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