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An introduction to chimeric antigen receptor (CAR) T-cell ... - PubMed
https://pubmed.ncbi.nlm.nih.gov/30680780/
Web ResultPMID: 30680780. DOI: 10.1002/ajh.25418. Abstract. Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen.
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Chimeric Antigen Receptor Therapy | New England Journal of Medicine
https://www.nejm.org/doi/full/10.1056/NEJMra1706169
Web ResultJul 4, 2018 · Chimeric Antigen Receptor (CAR) T Cells Engrafting, Trafficking to Tumor, and Proliferating Extensively after Infusion. Antitumor immunity comprises complementary innate and adaptive immune...
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CAR T cell - Wikipedia
https://en.wikipedia.org/wiki/CAR_T_cell
Web ResultIn biology, chimeric antigen receptors (CARs)—also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors—are receptor proteins that have been engineered to give T cells the new ability to target a specific antigen.
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Chimeric Antigen Receptor T-Cell Therapy - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK537294/
Web ResultOct 3, 2022 · Introduction. Chimeric antigen receptors (CARs) are recombinant receptors for antigens which redirect the specificity and function of T lymphocytes and/or other immune cells in a single molecule. The concept of using CARs in cancer immunotherapy is that CARs, which are programmed targeting tumor-associated …
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Chimeric antigen receptor (CAR) immunotherapy: basic principles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580929/
Web ResultSep 23, 2021 · With recent advances, chimeric antigen receptor (CAR) immunotherapy has become a promising modality for patients with refractory cancer diseases.
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CAR T Cells: Engineering Immune Cells to Treat Cancer - NCI
https://www.cancer.gov/about-cancer/treatment/research/car-t-cells
Web ResultMar 10, 2022 · They are made by collecting T cells from the patient and re-engineering them in the laboratory to produce proteins on their surface called chimeric antigen receptors, or CARs. The CARs recognize and bind to specific proteins, or antigens, on the surface of cancer cells.
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Recent advances and discoveries in the mechanisms and ... - Nature
https://www.nature.com/articles/s41568-020-00323-z
Web ResultJan 22, 2021 · After two decades of fine-tuning T cell engineering, the tremendous clinical success of chimeric antigen receptor (CAR) T cells in patients with leukaemia and lymphoma has led to an...
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Chimeric Antigen Receptor Therapy | NEJM
https://www.nejm.org/doi/10.1056/NEJMra1706169
Web ResultChimeric antigen receptor (CAR) T cells were recently approved by the Food and Drug Administration (FDA) and are poised to enter the practice of medicine for the treatment of leukemia and...
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CAR T-cell Therapy and Its Side Effects - American Cancer Society
https://www.cancer.org/cancer/managing-cancer/treatment-types/immunotherapy/car-t-cell1.html
Web ResultChimeric antigen receptor (CAR) T-cell therapy is a way to get immune cells called T cells (a type of white blood cell) to fight cancer by changing them in the lab so they can find and destroy cancer cells.
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Chimeric Antigen Receptor Therapy - PubMed
https://pubmed.ncbi.nlm.nih.gov/29972754/
Web ResultJul 5, 2018 · Chimeric Antigen Receptor Therapy N Engl J Med. 2018 Jul 5;379(1):64-73. doi: 10.1056/NEJMra1706169. Authors Carl H June 1 , Michel Sadelain 1 Affiliation 1 From the Center for Cellular Immunotherapies ... Receptors, Antigen, T-Cell / therapeutic use*
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