Keyword Analysis & Research: encorafenib
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Encorafenib Uses, Side Effects & Warnings - Drugs.com
https://www.drugs.com/mtm/encorafenib.html
WEBApr 26, 2023 · What is encorafenib? Encorafenib is used in combination with a medicine called binimetinib ( Mektovi) to treat melanoma ( skin cancer) that cannot be treated with surgery or has spread to other parts of the body.
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Encorafenib - Wikipedia
https://en.wikipedia.org/wiki/Encorafenib
WEBEncorafenib, sold under the brand name Braftovi, is a medication for the treatment of certain melanoma cancers. It is a small molecule BRAF inhibitor that targets key enzymes in the MAPK signaling pathway. This pathway occurs in many different cancers including melanoma and colorectal cancers.
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Encorafenib (Oral Route) Description and Brand Names - Mayo Clinic
https://www.mayoclinic.org/drugs-supplements/encorafenib-oral-route/description/drg-20443856
WEBMar 1, 2024 · Encorafenib is used in combination with binimetinib to treat melanoma (skin cancer) that has spread or cannot be removed by surgery. It is only used if the melanoma cells have the BRAF V600E or V600K mutations. Your doctor will use a special test to look for these mutations.
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Encorafenib: Uses, Interactions, Mechanism of Action - DrugBank …
https://go.drugbank.com/drugs/DB11718
WEBEncorafenib is a kinase inhibitor that targets BRAF V600E, as well as wild-type BRAF and CRAF in in vitro cell-free assays with IC50 values of 0.35, 0.47, and 0.3 nM, respectively. Mutations in the BRAF gene, such as BRAF V600E, can result in constitutively activated BRAF kinases that may stimulate tumor cell growth.
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FDA Approves Encorafenib for Colorectal Cancer - NCI
https://www.cancer.gov/news-events/cancer-currents-blog/2020/fda-encorafenib-cetuximab-metastatic-colorectal
WEBMay 8, 2020 · The Food and Drug Administration (FDA) has approved encorafenib (Braftovi) for the treatment of some patients with colorectal cancer. The approval covers using encorafenib in combination with cetuximab (Erbitux) in adults with metastatic colorectal cancer whose tumors have a mutation in the BRAF gene, called V600E.
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Encorafenib - NCI - National Cancer Institute
https://www.cancer.gov/about-cancer/treatment/drugs/encorafenib
WEBEncorafenib is approved to be used with other drugs to treat patients whose cancer has a certain mutation in the BRAF gene, including: Colorectal cancer that has spread to other parts of the body. It is used with cetuximab in adults …
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Encorafenib, Binimetinib, and Cetuximab in BRAF …
https://www.nejm.org/doi/full/10.1056/NEJMoa1908075
WEBSep 29, 2019 · Encorafenib is a BRAF inhibitor with more prolonged pharmacodynamic activity than other approved BRAF inhibitors. 26 The combination of the BRAF inhibitor encorafenib and the anti-EGFR...
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Braftovi (encorafenib) dosing, indications, interactions, adverse
https://reference.medscape.com/drug/braftovi-encorafenib-1000232
WEBencorafenib, pacritinib. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Encorafenib (a CYP3A4 inhibitor and inducer) may increase or decrease levels of pacritinib. voriconazole. encorafenib and voriconazole both increase QTc interval. Contraindicated. Serious - Use Alternative (235) adagrasib. adagrasib, encorafenib.
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Encorafenib Oral: Uses, Side Effects, Interactions, Pictures ... - WebMD
https://www.webmd.com/drugs/2/drug-175523/encorafenib-oral/details
WEBEncorafenib is used to treat certain types of cancer (such as lung cancer, melanoma skin cancer, cancer in the colon or rectum). Encorafenib belongs to a class of drugs known as kinase...
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Encorafenib: MedlinePlus Drug Information
https://medlineplus.gov/druginfo/meds/a618040.html
WEBEncorafenib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells. How should this medicine be used? Encorafenib comes as a capsule to take by mouth.
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