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Nicotinamide adenine dinucleotide phosphate - Wikipedia
https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide_phosphate
WEBNicotinamide adenine dinucleotide phosphate, abbreviated NADP + or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source').
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NAD(H) and NADP(H) Redox Couples and Cellular Energy …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737637/
WEBJan 1, 2018 · NAD + can be reduced to NADH via dehydrogenases and can also be phosphorylated to NADP + via NAD + kinases (NADKs). The NAD + /NADH redox couple is known as a regulator of cellular energy metabolism, that is, of glycolysis and mitochondrial oxidative phosphorylation.
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4.3: NAD and NADP - Biology LibreTexts
https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/04%3A_Cell_Metabolism/4.03%3A_NAD_and_NADP
WEBMay 14, 2022 · 4.3: NAD and NADP. Nicotinamide adenine dinucleotide (NAD) and its relative nicotinamide adenine dinucleotide phosphate (NADP) are two of the most important coenzymes in the cell. NADP is simply NAD with a third phosphate group attached as shown at the bottom of the figure.
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NAD+/NADH and NADP+/NADPH in cellular functions and cell …
https://pubmed.ncbi.nlm.nih.gov/18020963/
WEBAbstract. Accumulating evidence has suggested that NAD (including NAD+ and NADH) and NADP (including NADP+ and NADPH) could belong to the fundamental common mediators of various biological processes, including energy metabolism, mitochondrial functions, calcium homeostasis, antioxidation/generation of oxidative stress, gene expression ...
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NADPH - Definition and Function | Biology Dictionary
https://biologydictionary.net/nadph/
WEBApr 28, 2017 · NADPH Definition. NADPH is a cofactor, used to donate electrons and a hydrogens to reactions catalyzed by some enzymes. Typically enzymes involved in anabolic pathways that create large molecules use NADPH, while enzymes involved in the breakdown of molecules use the analog NADH.
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NADPH—The Forgotten Reducing Equivalent - PMC - National …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168431/
WEBNADPH is the major reducing equivalent driving de novo synthesis of fatty acids, cholesterol, amino acids, and nucleotides. Its other major function is generation of superoxide (O 2−) by NADPH oxidases (NOXs) and scavenging of H 2 O 2 by regenerating GSH and the antioxidant protein thioredoxin (TRX).
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The phosphate makes a difference: cellular functions of NADP
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067316/
WEBDec 2, 2013 · In its reduced form (NADPH), this molecule represents a universal electron donor, not only to drive biosynthetic pathways. Perhaps even more importantly, NADPH is the unique provider of reducing equivalents to maintain or regenerate the cellular detoxifying and antioxidative defense systems.
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NADPH homeostasis in cancer: functions, mechanisms and
https://www.nature.com/articles/s41392-020-00326-0
WEBOct 7, 2020 · NADPH-dependent biological functions in cancer. Both NAD (H) and NADP (H) are cofactors that are used for transferring and reserving reduction potential. 7, 9 Although the structures are...
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Reduced nicotinamide adenine dinucleotide phosphate in redox
https://www.nature.com/articles/s41401-021-00838-7
WEBJan 11, 2021 · NADH and NADPH are weakly fluorescent; in contrast, their oxidized counterparts NAD + and NADP + are not [ 14 ]. Based on its optical property, the weak endogenous fluorescence of NADPH has...
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NADPH production by the oxidative pentose-phosphate pathway
https://www.nature.com/articles/s42255-019-0043-x
WEBMar 11, 2019 · NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism | Nature Metabolism. Article. Published: 11 March 2019. NADPH production by the oxidative...
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