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What are the characteristics of patients enrolled in the NCDHHS?

Participant Characteristics: • 35% of patients enrolled in each arm were aged <50 years; 21% of patients were aged ≥ 70 years. • 21% to 23% of patients had diabetes mellitus, 20% to 21% had heart disease, and 6.5% to 7% had chronic lung disease.

What are the criteria for inclusion in a 3-arm RCT?

23 Open-label, 3-arm RCT in hospitalized adults (n = 667) Key Inclusion Criteria: • Aged ≥ 18 years • Clinically suspected or laboratory-confirmed SARS- CoV-2 infection • Mild or moderate COVID-19 • Duration of symptoms ≤ 14 days Number of Participants: • mITT analysis included patients with laboratory- confirmed SARS-CoV-2 infection (n = 504).

How common are ongoing symptoms in HCQ and placebo patients?

• Ongoing symptoms were reported by 24% of those in HCQ arm and 30% of those in the placebo arm at Day 14 P = 0.21). • No difference in the incidence of hospitalization between the arms (4 patients in the HCQ arm vs. 10 patients

What is the number of participants in the HCQ study?

Number of Participants: • ITT analysis: HCQ (n = 947) and HCQ control (n = 906) • Enrollment occurred between March 22 and October 4, 2020. Participant Characteristics:

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