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Paget's Disease of Bone | MedlinePlus
Jun 19, 2021 · Paget's disease can lead to other complications, such as: Arthritis, because the misshapen bones can cause increased pressure and more wear and tear on the joints; Heart failure. In severe Paget's disease, the heart has to work harder to pump blood to affected bones.
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Paget's disease of bone - Symptoms and causes - Mayo Clinic
Feb 03, 2021 · The cause of Paget's disease of bone is unknown. Scientists suspect a combination of environmental and genetic factors contribute to the disease. Several genes appear to be linked to getting the disease. Some scientists believe Paget's disease of bone is related to a viral infection in your bone cells, but this theory is controversial. Risk factors
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Paget's disease of bone - NHS
Read more about how Paget's disease of bone is treated. Further problems caused by Paget's disease of bone. Paget's disease of bone can sometimes lead to further, potentially serious problems. These include: fragile bones that break more easily than normal; enlarged or misshapen bones; permanent hearing loss (if the skull is affected)
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Paget's Disease of Bone - Symptoms and Treatment
Paget's disease of bone is a chronic disease of the skeleton. In healthy bone, a process called remodeling removes old pieces of bone and replaces them with new, fresh bone. Paget’s disease causes this process to shift out of balance, resulting in new bone that is abnormally shaped, weak, and brittle.
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Paget's Disease - Pathology - Orthobullets
Paget's Disease is an idiopathic condition of abnormal bone remodeling with normal bone being replaced through an active interplay between excessive bone resorption and abnormal new bone formation. The condition typically present in patients age > 40 with asymptomatic lesions discovered incidentally on radiographs.
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Paget's disease of the breast - PMC
Dec 08, 2011 · Mammary Paget's disease (MPD) is almost always associated with an underlying breast cancer in 92–100% of cases.[11,12] Approximately 50% of this patients present with an associated palpable mass in the breast.[3,4] In cases where mass is palpable, invasive carcinoma is likely to be found.On the other hand, patients presenting without a clinical mass more likely …
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Paget Disease of the Breast - NCI
Kanitakis J. Mammary and extramammary Paget's disease. Journal of the European Academy of Dermatology and Venereology 2007;21(5):581–590. [PubMed Abstract] Kawase K, Dimaio DJ, Tucker SL, et al. Paget's disease of the breast: there is a role for breast-conserving therapy. Annals of Surgical Oncology 2005;12(5):391–397. [PubMed Abstract]
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Paget's disease of the nipple - NHS
The term Paget's disease of the nipple is used to distinguish the condition from Paget's disease of the bone (where bones become weak and deformed). Symptoms of Paget's disease of the nipple. Paget's disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola.
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Paget's disease of bone - Better Health Channel
Paget's disease of bone is a chronic condition that causes abnormal enlargement and weakening of bones. Any part of the skeleton can be affected, but the most common sites include the skull, spine, pelvis, thigh bone, shin and the bone of the upper arm.
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Paget's disease of the breast - Symptoms and causes - Mayo
May 20, 2021 · Paget's disease of the breast occurs most often after age 50. Most people with this diagnosis also have underlying ductal breast cancer, either in situ — meaning in its original place — or, less commonly, invasive breast cancer. Only rarely is Paget's disease of the breast confined to the nipple itself.
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