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The use of viral vectors in vaccine development | npj Vaccines
https://www.nature.com/articles/s41541-022-00503-y
WEBJul 4, 2022 · Adenovirus-based vectors can be either replication-competent or replication-defective, depending on whether or not they contain the entire early 1 (E1) region or part of it 10.
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Replication-Competent Adenovirus Assays Reduce …
https://www.criver.com/insights/replication-competent-adenovirus-assays-contamination-risk
WEBJun 18, 2020 · Historically, adenovirus vectors have been produced using human embryonic kidney cells (HEK293), which were transformed using human adenovirus 5. These cells contain the E1 region of adenovirus and can aid in the replication of replication-incompetent adenovirus vectors.
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Detection Assay for Replication-Competent Adenovirus by
https://pubmed.ncbi.nlm.nih.gov/31792138/
WEBDec 2, 2019 · Detection Assay for Replication-Competent Adenovirus by Concentration Passage and Real-Time Quantitative Polymerase Chain Reaction (qPCR) Cold Spring Harb Protoc. 2019 Dec 2;2019 (12). doi: 10.1101/pdb.prot095588. Authors. Martin Lock , Mauricio Alvira , James Wilson , Miguel Sena-Esteves , Guangping Gao. PMID: 31792138.
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Who’s afraid of replication-competent adenoviruses?
https://www.nature.com/articles/3300902
WEBMay 14, 1999 · Replication-competent adenoviruses derived from rAV that are currently known are similar to wild-type adenoviruses, except that in most cases the E3 region is deleted, which has...
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Adenovirus Vectors for Gene Therapy, Vaccination and Cancer …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507798/
WEBReplication-competent (oncolytic) vectors are employed for cancer gene therapy. Oncolytic vectors are engineered to replicate preferentially in cancer cells and to destroy cancer cells through the natural process of lytic virus replication.
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Replication-competent adenovirus formation in 293 cells: the
https://pubmed.ncbi.nlm.nih.gov/15827158/
WEBPropagation of E1 region replacement adenovirus vectors in 293 cells results in the rare appearance of replication-competent adenovirus (RCA). The RCA genome contains E1 DNA acquired from the 293 cellular genome. The Luria-Delbruck fluctuation test was adapted to measure RCA formation rates.
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A fully replication-competent adenovirus vector with enhanced …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437749/
WEBReplication-competent (oncolytic) adenovirus (Ad) vectors have been developed as a promising new tool in the fight against cancer. 1 The principal idea behind this approach is that the vector replicates in the cancer cell, lyses the infected cell at the culmination of infection and releases progeny virus.
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No more helper adenovirus: production of gutless adenovirus
https://www.nature.com/articles/s12276-019-0334-z
WEBOpen access. Published: 28 October 2019. No more helper adenovirus: production of gutless adenovirus (GLAd) free of adenovirus and replication-competent adenovirus (RCA) contaminants....
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A qPCR-Based Method for Quantification of Replication Competent
https://pubmed.ncbi.nlm.nih.gov/35733002/
WEBProduction of conditionally replicating adenoviruses may unfortunately generate undesired replication-competent adenovirus (RCA) which raises safety concerns in clinical usage. Cell-based assays can detect RCA in batches of nonreplicating adenoviral vectors but cannot distinguish RCA from conditionally replicating oncolytic adenoviruses.
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Adenovirus DNA Replication - PMC - National Center for …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578361/
WEBAbstract. Adenoviruses have attracted much attention as probes to study biological processes such as DNA replication, transcription, splicing, and cellular transformation. More recently these viruses have been used as gene-transfer vectors and oncolytic agents.
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