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Meeting FDA Guidance recommendations for replication-competent virus and insertional oncogenesis testing
https://www.sciencedirect.com/science/article/pii/S2329050122001681
WEBMar 9, 2023 · Replacing the gammaretroviral genome with a transgene of interest generates a replication-defective virus (vector) that is capable of high-efficiency gene transfer ( Figure 1 A ). The vector must be packaged into a virion, which is accomplished by independently expressing the viral genes ( Figure 1 B).
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Meeting FDA Guidance recommendations for replication-competent virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791246/
WEBMar 3, 2023 · Meeting FDA Guidance recommendations for replication-competent virus and insertional oncogenesis testing - PMC. Journal List. Mol Ther Methods Clin Dev. v.28; 2023 Mar 9. PMC9791246. As a library, NLM provides access to scientific literature. DOI: 10.1016/j.omtm.2022.11.009 Published: 2023/03/03
DOI: 10.1016/j.omtm.2022.11.009
Published: 2023/03/03
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Replication-Competent Viruses as Cancer Immunotherapeutics: Emerging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968310/
WEBAug 1, 2015 · Replication-competent (oncolytic) viruses (OV) are not similarly limited to certain indications, as they can, via oncolysis, release the unique tumor epitopes from each patient's own tumor and can, therefore, be considered as in situ vaccines. Author: Dmitriy Zamarin, Sari Pesonen Publish Year: 2015 DOI: 10.1089/hum.2015.055 Publication: Hum Gene Ther. 2015 Aug 1; 26(8): 538-549.
Author: Dmitriy Zamarin, Sari Pesonen
Publish Year: 2015
DOI: 10.1089/hum.2015.055
Publication: Hum Gene Ther. 2015 Aug 1; 26(8): 538-549.
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A Comparative Study of Replication-Incompetent and -Competent
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443908/
WEBJun 6, 2017 · Here, we analyzed the adaptive immune system’s response following viral infection by comparing replication-incompetent and replication-competent adenoviral vectors. Our findings suggest that cell death caused by replication-competent adenoviral vectors is required to induce a significant anti-tumor immune response and survival benefits in ... Author: Julius W. Kim, Jason Miska, Jacob S. Young, Aida Rashidi, J. Robert Kane, Wojciech K. Panek, Deepak ... Publish Year: 2017 DOI: 10.1016/j.omto.2017.05.001 Publication: Mol Ther Oncolytics. 2017 Jun 16; 5: 97-104.
Author: Julius W. Kim, Jason Miska, Jacob S. Young, Aida Rashidi, J. Robert Kane, Wojciech K. Panek, Deepak ...
Publish Year: 2017
DOI: 10.1016/j.omto.2017.05.001
Publication: Mol Ther Oncolytics. 2017 Jun 16; 5: 97-104.
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Meeting FDA Guidance recommendations for replication-competent virus
https://pubmed.ncbi.nlm.nih.gov/36588821/
WEBDec 2, 2022 · Meeting FDA Guidance recommendations for replication-competent virus and insertional oncogenesis testing. Mol Ther Methods Clin Dev. 2022 Dec 2:28:28-39. doi: 10.1016/j.omtm.2022.11.009. eCollection 2023 Mar 9.
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Defective viral genomes are key drivers of the virus–host interaction
https://www.nature.com/articles/s41564-019-0465-y
WEBJun 3, 2019 · Main. Viruses are remarkably resilient microorganisms able to adapt and survive in the complex host physiological and immune environment. Accumulating evidence demonstrates that viruses can...
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Replication-Competent Viruses as Cancer Immunotherapeutics: Emerging
https://pubmed.ncbi.nlm.nih.gov/26176173/
WEBReplication-competent (oncolytic) viruses (OV) as cancer immunotherapeutics have gained an increasing level of attention over the last few years while the clinical evidence of virus-mediated antitumor immune responses is still anecdotal.
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Organ-specific genome diversity of replication-competent SARS ... - Nature
https://www.nature.com/articles/s41467-021-26884-7
WEBNov 16, 2021 · We report a detailed virological analysis of thirteen postmortem coronavirus disease 2019 (COVID-19) cases that provides proof of viremia and presence of replication-competent SARS-CoV-2 in...
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