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GWAS: why is replication in another cohort so crucial?
https://biology.stackexchange.com/questions/31430/gwas-why-is-replication-in-another-cohort-so-crucial
Apr 17, 2015 · A replication cohort does not need to be huge and the actual size needed will largely depend on the effect size of the SNP seen in the discovery cohort. A "power-to-detect" calculation would help in predicting the cohort size needed. Reviews: 2
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Replication cohort in microbial GWAS. - ResearchGate
https://www.researchgate.net/post/Replication_cohort_in_microbial_GWAS
Replication cohort in microbial GWAS. Replication in an independent cohort is of course the gold standard in GWAS studies, and many high profile …
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Characteristics of the Discovery and Replication Cohorts
https://www.researchgate.net/figure/Characteristics-of-the-Discovery-and-Replication-Cohorts_tbl1_321414391
Replication of the 31 discovery CpG sites was sought in multiethnic meta-analyses of an additional six cohort studies (N ¼ 7,182). ... View in full-text Context 3 ... is in the first intron of...
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Replication Cohort Latest Research Papers | ScienceGate
https://www.sciencegate.app/keyword/154990
Find the latest published documents for Replication Cohort, Related hot topics, top authors, the most cited documents, and related journals
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Acute kidney injury in the UK: a replication cohort study …
https://pubmed.ncbi.nlm.nih.gov/29961002/
Design: Population-based cohort study analysing data from electronic health records from three regions in the UK through shared analysis code and harmonised methodology. Setting: Three populations from Scotland, Wales and England covering three time periods: Grampian 2003, 2007 and 2012; Swansea 2007; and Salford 2012. Author: Simon Sawhney, Heather A Robinson, Sabine N van der Veer, Hilda O Hounkpatin, Timothy M Scale, James... Publish Year: 2018
Author: Simon Sawhney, Heather A Robinson, Sabine N van der Veer, Hilda O Hounkpatin, Timothy M Scale, James...
Publish Year: 2018
DA: 100 PA: 85 MOZ Rank: 43
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Replication cohorts in microbial GWAS - Biology Stack Exchange
https://biology.stackexchange.com/questions/62572/replication-cohorts-in-microbial-gwas
Replication in an independent cohort is of course the gold standard in GWAS studies, and many high profile journals will now (quite rightly) not accept finding indicating a phenotype genotype association without evidence of replication.
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Replication in genome-wide association studies - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865141/
Nov 01, 2009 · Replication may also be useful in identifying a more reliable estimate of the effect size for the association. Signals selected based on statistical significance thresholds in underpowered settings are likely to have (on average) inflated effects due to the winner’s curse phenomenon. ... others may have been cohort or cross-sectional studies.
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